Water soluble chitosan in toothpaste and mouthwash
Water-soluble chitosan refers to a type of chitosan that can be dissolved in neutral water, mainly including chitosan with a moderate degree of deacetylation, chitosan salt, and carboxymethyl chitosan. Chitin is obtained by deacetylation and modification, and it is widely distributed in nature. It exists in the shells of aquatic arthropods such as shrimps and crabs, and the exoskeletons of mollusks and fungi. Moderately deacetylated chitosan refers to chitosan with a uniform degree of deacetylation of about 55% in the internal structure of the molecule. The crystalline form inside the molecule of this type of chitosan is different from that of chitosan because it is partially deacetylated. , So the original secondary structure of the molecular chain is destroyed, making the crystal almost impossible to set, so it has the characteristic of being soluble in neutral water. Chitosan salt is a type of water-soluble chitosan made by co-dissolving chitosan and acid according to the characteristic that chitosan is a weakly basic ionomer. Chitosan salt can be dissolved in neutral water, and the pH value of its aqueous solution does not change much. Carboxymethyl chitosan is a modified product obtained by carboxymethylation of chitosan as raw material. Carboxymethyl chitosan can be dissolved in water and alkaline aqueous solution but is insoluble under acidic conditions. Methyl chitosan has a good antibacterial effect in the solution under neutral conditions. Because the role of water-soluble chitosan is exactly the same as that of chitosan, water-soluble chitosan has greatly expanded the application fields of chitosan. Water-soluble chitosan is a type of chitosan with a variety of chemical structures. Because of their different structures, their uses are also different.
Water-soluble chitosan is a biological material with great application . It is now used as an auxiliary material or directly used in the food, chemical, and pharmaceutical industries:
(1) Chitosan with a low degree of deacetylation. The application fields of such substances are still relatively few developed. They are mainly used as soil amendments in agriculture and as thickeners in the food field.
(2) Chitosan hydrochloride can be used in the field of medicine to make certain antibacterial medical materials, such as gauze. It can be used as a biochemical reagent with special functions in the field of bioengineering.
(3) Carboxymethyl chitosan is mainly used in the fields of medicine and cosmetics because of its good bacteriostatic biological affinity and strong moisturizing properties. Such as the preparation of wound dressings for scalds or mechanical injuries: disinfectants used after wound infections and cosmetics for beauty and moisturizing. it also be used as a food preservative.
Through experiments, water-soluble chitosan has the function of bactericidal and antipruritic. According to experiments, 0.1-20% of water-soluble chitosan has a bactericidal effect on both Gram-positive and Gram-negative groups, and positively charged cation groups The bacteria that grow in the oral cavity and the negative ions of grease all have an affinity to achieve the effects of sterilization, bacteriostasis, mothproofing and anti-inflammatory.
Water-soluble chitosan positively charged cationic grease has a unique affinity. 0.1-20% of water-soluble chitosan can quickly combine with the surface of the tooth and oral cavity to form a barrier membrane, covering the surface, activating cells, and promoting surface capillary The microcirculation of blood vessels can arouse the response of deep immune cells and repair the sores formed by ulcers.
As an oral health care product, water-soluble chitosan must have a degree of deacetylation of more than 80%. Water-soluble chitosan can be dissolved in neutral solutions such as water. When the concentration of the water-soluble chitosan aqueous solution is 0.1-8%, it can have good antibacterial and anti-inflammatory effects. In actual application, toothpaste and mouthwash with water-soluble chitosan content of 1-15% are made, which is more convenient to use and easy to be accepted by consumers.
The preparation of the water-soluble chitosan stock solution is to dissolve 250g of 80% water-soluble chitosan with a degree of deacetylation in 0.9%, 750ml of physiological saline, filter in a box to remove impurities, and obtain a water-soluble shell with a degree of deacetylation of 80% Glycan solution, sterilization, and disinfection.
To prepare a mouthwash containing 2.5% water-soluble chitosan, 250 g of water-soluble chitosan with a degree of deacetylation of 80% is added to 0.9% saline to dissolve and deionized water to 1000ml, and stir to obtain 25% water-soluble chitosan. Sugar concentrate. Take 400ml of 25% water-soluble chitosan concentrate, add 1.3 grams of vitamin B, a little flavor, and then filter and sterilize to prepare a mouthwash containing 2.55% water-soluble chitosan.
To prepare a toothpaste containing 2.5% water-soluble chitosan. After the toothpaste is made into a paste, water-soluble chitosan is added according to the weight ratio to prepare a toothpaste containing 2.5% water-soluble chitosan.