Application of HPMC E5 in Tablet Film Coating
Hydroxypropyl Methylcellulose (HPMC) E5 is a low-viscosity, non-ionic cellulose ether widely used as a film-former for immediate-release tablet coatings. Its combination of rapid dissolution, excellent film integrity and high sprayability makes it a preferred excipient in pharmaceutical and nutraceutical coating systems.
What is HPMC E5?
HPMC E5 is a cellulose derivative with a nominal viscosity of approximately 5 mPa·s (2% aqueous solution at 20 °C). It is odorless, tasteless and meets major pharmacopeial standards including USP, EP and ChP.
Why HPMC E5 is ideal for tablet film coating
1. Excellent film-forming properties
Produces uniform, transparent and mechanically robust films with smooth surfaces and low defect rates.
2. Fast dissolution for immediate-release tablets
Low viscosity and rapid hydration enable quick disintegration and release, preserving the IR profile of the core tablet.
3. Easy processing and sprayability
Low solution viscosity allows higher solids loading and improved atomization in pan or fluid-bed coating, reducing coating time and nozzle fouling risk.
4. Excellent compatibility
Compatible with common plasticizers (PEG, propylene glycol, glycerin), pigments (iron oxides, TiO2) and APIs. Works well in fully aqueous systems, avoiding organic solvents.
Primary functions of HPMC E5 film coatings
- Improve tablet appearance and color uniformity
- Mask unpleasant taste and odor
- Enhance mechanical strength and reduce friability
- Protect against moisture, light and oxygen
- Improve stability during storage and transport
Typical formulation & usage
Common use levels and processing guidelines:
- Inclusion level: 2–5% (w/w) of the coating suspension (adjust per core and target film thickness)
- Coating weight gain: Typically 2–4% of tablet weight for aesthetic/functional coatings
- Plasticizers: PEG 400, propylene glycol or glycerin (1–3% of dry polymer) to improve film flexibility
- Processing tip: Use moderate inlet temperature and controlled spray rate to avoid tackiness and ensure uniform drying
Applications across industries
- Pharmaceutical immediate-release tablets (OTC and Rx)
- Vitamins and mineral tablets
- Nutraceuticals and dietary supplements
- Herbal and traditional medicine tablets
Conclusion
HPMC E5 is a reliable, efficient and cost-effective polymer for tablet film coatings where rapid dissolution and excellent film quality are required. Its low viscosity, formulation flexibility and aqueous compatibility make it a go-to choice for immediate-release formulations.
If you need formulation support, sample inquiries or technical documentation, please contact us or view the product page: HPMC E5 product details.